Senior Scientist, Antibody Engineering

Company: Valid8 Financial, Inc.
Location: San Francisco
Posted on: March 30, 2025

Job Description:

Senior Scientist Antibody EngineeringMarch 2025Position Summary:Join our innovative team at TCG Labs-Soleil as an antibody engineering expert! We are seeking a highly skilled and motivated scientist to lead and advance our antibody engineering capabilities within the cutting-edge Biologics Technology Group. In this pivotal role, you will develop and optimize antibody-based therapeutics while integrating computational and structural insights. You will collaborate cross-functionally with scientists across research and early development to drive technical excellence and support our growing pipeline of protein and antibody-based therapeutics.Responsibilities:

• Directly contribute to the therapeutic pipeline by developing and optimizing antibody engineering strategies, including humanization, affinity maturation, bispecific and multispecific antibody design, and innovative molecular formats.
• Evaluate and implement cutting-edge antibody display technologies (e.g., phage, yeast, or mammalian display) to enhance discovery and screening capabilities.
• Collaborate closely with protein sciences, structural biology, and bioinformatics teams to integrate computational design with experimental validation.
• Drive technology innovation by staying current with emerging trends in antibody engineering and incorporating advances into the team's workflows.
• Troubleshoot and resolve complex technical challenges related to in vitro antibody discovery, engineering, and characterization.
• Work cross-functionally with internal teams and external partners, CROs, and academic collaborators to expand antibody engineering capabilities.
• Design, implement, and analyze experiments efficiently, delivering data-driven insights that inform pipeline decisions.Qualifications:
• Ph.D. with 5+ years of postdoctoral or industry experience or M.S. with 10+ years of industry experience in antibody discovery, engineering, biochemistry, structural biology, or related fields within biotech or pharm.
• Deep expertise in in vitro antibody discovery and optimization, including synthetic and immune library construction for lead identification and optimization.
• Proficiency in phage, yeast, or mammalian display technologies for antibody discovery, optimization, and affinity maturation.
• Strong problem-solving skills with the ability to troubleshoot complex molecular and biochemical challenges.
• Demonstrated ability to prioritize tasks and manage multiple projects in a dynamic, fast-paced environment.
• Meticulous attention to experimental detail, adept at multitasking and managing concurrent experiments without compromising quality.
• Excellent oral and written communication skills, with a track record of presenting scientific findings and contributing to publications or patents.
• Strong team player with the ability to lead cross-functional collaborations and with flexibility to adapt to new scientific domains and quickly acquire new techniques.Company OverviewTCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel 'venture capital-biotech' model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.Benefits and CompensationTCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.The anticipated salary range for fully qualified candidates applying for this role will be $126,500 - $180,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn't have a signed agreement with TCG Labs-Soleil.
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Keywords: Valid8 Financial, Inc., San Francisco , Senior Scientist, Antibody Engineering, Engineering , San Francisco, California