Senior Scientist - Discovery Biotherapeutics

Company: Disability Solutions
Location: Brisbane
Posted on: November 3, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit. Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma. Bristol Myers Squibb is seeking a highly motivated and innovative Scientist with demonstrated expertise in protein production to join our Discovery Biotherapeutics team. The successful candidate will be in the antigen technologies group and will collaborate closely with scientists in discovery biotherapeutics, biology, and other related groups. The candidate will be responsible for the recombinant protein production, including the design, expression, purification, and characterization. These proteins will be used in the binder discovery process and applied in biophysical experiment and structural biology to support BMS biotherapeutics programs.Responsibilities:

• Lead the antigen protein production by conducting recombinant protein construct design, expression, and purification at a milligram scale for early discovery research purposes.
• Analyze and characterize the protein quality to ensure sample quality meets the requirements for intended experiments.
• Optimize and troubleshoot expression and purification processes for challenging protein production.
• Conduct the membrane production at a milligram scale in detergent or detergent-free forms (amphipol, nanodisc), starting from the construct design, screen, expression test, to the large-scale productions, to support the binder discovery workflow and biophysical experiments.
• Manage lab equipment organization and maintenance.
• Serve as the point of contact on protein properties, manage the production requests, and communicate results.
• Collaborate with multiple project team members in discovery biotherapeutics and biology.
• Ensure proper planning and execution of experiments, adhering to timelines and project objectives.
• Accomplish goals under project team time lines.Basic Qualifications:
  • BS degree with 7+ years of industry experience or MS degree with 5+ years of industry experience or PhD with 2 year academic/industry experience with Biochemistry, Biophysics, or similar field. Preferred Qualifications:
    • Deep knowledge and experience of protein biochemistry and structural biology.
    • PhD and 2+ years of relevant experience
    • Extensive experience in mammalian culture (HEK293, CHO) for recombinant protein expression.
    • Extensive experience in recombinant protein purification using various techniques such as affinity, ion exchange, and size exclusion chromatography at a milligram scale using AKTA Avant.
    • Experience in protein analytical characterization including SDS-PAGE/CE-SDS, endotoxin, analytical SEC, SEC-MALS, Mass photometry, LC/MS, etc
    • Experience in membrane protein production such as GPCR, transporter, and receptor is plus.
    • Knowledge and experience in structural biology such as X-ray crystallography and cryoEM and computational modeling (AlphaFold2, etc) is a plus.
    • Experience in antibody production for in vitro or in vivo usages is a plus.
    • Knowledge and experience with CROs for custom protein production is a plus.
    • Demonstrate excellent written and oral communication skills.
    • Excellent time management and organizational skills.
    • Ability to work in a multidisciplinary biologics discovery team.The starting compensation for this job is a range from $109,000 - $150,700 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, San Francisco , Senior Scientist - Discovery Biotherapeutics, Other , Brisbane, California