Sr. Principal Scientist/Scientific Lead, Bioconjugation

Company: Initial Therapeutics, Inc.
Location: San Francisco
Posted on: April 3, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.Overview:At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.Position Summary:Lilly Oncology's Large Molecule Discovery team is looking for a Sr. Principal Scientist/Scientific Lead in Chemistry/Biochemistry to support our growing biologics portfolio. This role will support Antibody-drug conjugates (ADCs) linker and payload design, develop conjugation technologies, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. He/she will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.Responsibilities:

• Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs.
• Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing novel chemistries to generate bioconjugates.
• Develop purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration.
• Characterize ADCs using UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS.
• Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents.
• Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences.
• Engage with multidisciplinary project teams to design, execute, and interpret experiments.
• Demonstrated record of scientific accomplishments and publications.
• Present periodic updates and reports to management team.
• Contribute to the long-term strategies for innovative solutions and intellectual property for securing FTO for Lilly.
• Maintain a safe, pleasant, and efficient working environment.Basic Requirements:
  • A minimum of a bachelor's degree in chemistry, Biochemistry, or other related scientific discipline with a record of minimum 8 years lab-based independent research experience is required. Master's or Ph.D. degree with 2-4+ years of relevant experience is highly preferred.
  • Deep expertise in using state-of-the-art conjugation methods and handling of highly potency cytotoxic payloads.Additional Preferences:
    • Strong hands-on experience producing and characterizing antibody and protein drug conjugates using HIC, SEC, LC-MS, IEX, and RP-HPLC.
    • Experience with protein purification systems is preferred with hands-on experience and proficiency working with AKTA FPLCs.
    • Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
    • Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
    • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
    • Excellent written and verbal communicator.
    • Detail oriented and well organized.
    • Enthusiastic, self-motivated, and keen to improve processes.Physical Demands/Travel:The physical demands of this job are consistent with a laboratory/bench environment. Some light lifting, and maneuvering may be required.Work Environment:This position's work environment is in a laboratory/bench environment.Additional Information:Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $122,250 - $195,800. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
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Keywords: Initial Therapeutics, Inc., San Francisco , Sr. Principal Scientist/Scientific Lead, Bioconjugation, Other , San Francisco, California